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Two to Tango – Phosphorylation and Ubiquitination in IKK activation. Mechanism of IKK (Inhibitor of Kappa B Kinase) complex activation by inducible Phosphorylation and Ubiquitination in T Cell Receptor pathway

Код 893648

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Аннотация к книге "Two to Tango – Phosphorylation and Ubiquitination in IKK activation. Mechanism of IKK (Inhibitor of Kappa B Kinase) complex activation by inducible Phosphorylation and Ubiquitination in T Cell Receptor pathway"

Nuclear Factor – kappa B (NF-?B) is a major transcription factor that controls the survival and functioning of cells. Deregulated NF-?B is associated with auto-immune disorders and Cancer. NF-?B in T cells decides the fate of an immune reaction. NF-?B is turned on by T cell receptor (TCR) activation by a signaling cascade that involves CARMA1-BCL10-MALT1 (CBM) and Inhibitor of kappa B kinase (IKK) complex. TCR inducibly phosphorylates and ubiquitinates IKK complex to activate NF-?B. However,...

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Издательство: Книга по требованию
Дата выхода: июль 2011
ISBN: 978-3-6391-5816-8
Объём: 140 страниц
Масса: 233 г
Размеры(высота, ширина, толщина), см: 23 x 16 x 1

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