Coagulation protein FVIII binding to phospholipid membranes....
Hanna Engelke
Dynamics and interactions of proteins and membranes are essential biological processes. Fluorescence Correlation Spectroscopy allows one to measure these dynamics and interactions quantitatively in buffer as well as in their biological environment. Here, the mechanism of coagulation factor VIII binding to membranes, a key element in the intravascular pathway of the coagulation cascade, is investigated using Fluorescence Correlation Spectroscopy. The interplay of factor VIII binding with competing proteins is studied on the example of annexin V. The latter has a very efficient regulatory influence on factor VIII binding, which is modeled quantitatively. The natural environment can strongly influence biological processes, such as...
ISBN: 978-3-8381-1772-0
Издательство:
Книга по требованию
Дата выхода: июль 2011