Controlled Release of Drugs from Liposomes Using Ultrasound. A view...
Avi Schroeder, Joseph Kost, Yechezkel Barenholz
Liposomes, vesicles with one or more lipid bilayers entrapping an inner aqueous core, are widely used as drug delivery systems. When liposomes are smaller than 100 nanometers (nano liposomes) they have a unique capability of selectively accumulating in tumors and inflamed tissues. This phenomenon, known as the enhanced permeability and retention (EPR) effect, is related to the relatively high ‘leakiness' of blood vessels in these diseased tissues. In this book, we present a novel approach for triggering drug release from liposomes at the target site, by use of a remote trigger – low frequency ultrasound. The book includes detailed descriptions of formulation, characterization, and in vivo performance of liposome-based drugs, with...
ISBN: 978-3-6392-4728-2
Издательство:
Книга по требованию
Дата выхода: июль 2011