Deamidation
Frederic P. Miller, Agnes F. Vandome, John McBrewster
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Deamidation is a chemical reaction in which an amide functional group is removed from an organic compound. In biochemistry, the reaction is important in the degradation of proteins because it damages the amide-containing side chains of the amino acids asparagine and glutamine. In the biochemical deamidation reaction, the side chain of an asparagine attacks the following peptide group, forming a symmetric succinimide intermediate. The symmetry of the intermediate results in two products of its hydrolysis, either aspartate or in isoaspartate, which is a beta amino acid. This process is considered a deamidation...
ISBN: 978-6-1337-2675-8
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Книга по требованию
Дата выхода: июль 2011