Galectin-1 and apoptosis. Induction of apoptosis in galectin-1...
Ehab Aboueladab
Galectin-1 (gal-1), a member of the family of beta galactoside binding proteins, participates in several biological processes such as immunomodulation, cell adhesion, regulation of cell growth and apoptosis. The aim of this study was to investigate whether gal-1 the mechanisms of T cell activation on the level of signal transduction induced by galectin-1 (gal-1) having immunosuppressive activity. Gal-1 recognizes and cross-links appropriate glycoepitopes (Gal?1- 4GlcNAc- sequences) on T cell activation markers (CD2, CD3, CD45) and stimulates in parallel several interacting signalling pathways leading to suppression of the expression of Th1 cytokines and to apoptosis in thymocytes, activated T- cells, and in leukemic T cell lines. In...
ISBN: 978-3-8383-3483-7
Издательство:
Книга по требованию
Дата выхода: июль 2011