Analytical methods for studying the stability of protein molecules....
Jasmina Tonic - Ribarska, Suzana Trajkovic-Jolevska
During the past two decades, recombinant DNA technology brought about a significant increase in the number of protein drugs. The development of analytical techniques enables a high degree of clarification of the recombinant proteins, which in turn, brings about a significant decrease of the adverse effects. In spite of that, one of the capital problems, and challenges in the development of protein pharmaceuticals remains unsolved: the physical and chemical instability/degradation of proteins, which is in close connection with the appearance of toxicity through the stimulation of immune and/or allergic reactions, only to result with a decrease or a complete loss of the biological activity in the end. In this book we establish the HPLC...
ISBN: 978-3-8383-4854-4
Издательство:
Книга по требованию
Дата выхода: июль 2011