Atomic Force Microscope and Cell Biology. The mechanical properties...
Charles Roduit
This book describes the doctoral thesis where we explore the mechanical properties of living cells using the Atomic Force Microscope (AFM). The cell membrane contains lipids microdomains, called rafts, enriched in cholesterol and sphingolipids. The lipid rafts are believed to play an important role in signal processing by acting as a ”signaling platform”. The mechanical properties of these rafts were characterized by targeting one of its component, the GPI-anchored protein. This work revealed these domains to be stiffer than the surrounding membrane. The stiffness specificity of rafts may be related to the lower diffusion rate of proteins and can be, therefore, an important property for its role as a signaling platform. During this...
ISBN: 978-3-6391-8720-5
Издательство:
Книга по требованию
Дата выхода: июль 2011