Studies on Gag Membrane Binding and HIV-1 Viral Assembly
Paxton Provitera
HIV has taken the lives of over twenty million people with an additional forty million people currently infected. During the viral life-cycle, an HIV protein, Gag, assembles at the host membrane, specifically at lipid raft regions, at very high concentrations leading to viral particle budding. During a subsequent phase, maturation, Gag is processed into four proteins, matrix (MA), capsid (CA), nucleocapsid (NC) and p6. CA, the major dimerazation domain within Gag, forms the viral core that encapsulates the viral RNA and accessory proteins. Interestingly, within CA is a 20 amino acid stretch of conserved residues, the Major Homology Region (MHR), which form a tightly packed amphipathic helix. Here we have analyzed the membrane binding of...
ISBN: 978-3-6390-2598-9
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Книга по требованию
Дата выхода: июль 2011