Son of Sevenless
Lambert M. Surhone, Mariam T. Tennoe, Susan F. Henssonow
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. In cell signalling, Son of Sevenless (SOS) refers to a set of genes encoding guanine nucleotide exchange factors that act on the Ras subfamily of small GTPases. Ras-GTPases act as molecular switches that bind to downstream effectors, such as the protein kinase c-Raf, and localise them to the membrane resulting in their activation. Ras-GTPases are considered inactive when bound to guanosine diphosphate (GDP), and active when bound to guanosine triphosphate (GTP). As the name implies, Ras-GTPases possess intrinsic enzymatic activity that hydrolyses GTP to GDP and phosphate. Thus, upon binding to GTP, the duration...
ISBN: 978-6-1334-0252-2
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Книга по требованию
Дата выхода: июль 2011