High Quality Content by WIKIPEDIA articles! Pralatrexate (brand name Folotyn) is an anti-cancer therapy. It is the first drug approved as a treatment for patients with relapsed or refractory peripheral T-cell lymphoma, or PTCL — a biologically diverse group of aggressive blood cancers that have a poor prognosis.
High Quality Content by WIKIPEDIA articles! Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. This drug works similarly to Merck Co.`s Singulair (montelukast). It is currently under clinical trials.
High Quality Content by WIKIPEDIA articles! Prasugrel (marketing name Effient in the US, Efient in the EU and Prasita in India) is a novel platelet inhibitor developed by Daiichi Sankyo Co. and produced by Ube and currently marketed in the United States in cooperation with Eli Lilly and Company for acute coronary syndromes planned for percutaneous coronary intervention (PCI). Prasugrel was approved for use in Europe in February 2009, and is currently available in the UK. On July 10, 2009, the US Food and Drug Administration approved the use of prasugrel for the reduction of thrombotic cardiovascular events (including stent thrombosis) in patients with acute coronary syndrome who are to be managed with PCI.
High Quality Content by WIKIPEDIA articles! Pravadoline (WIN 48,098) is an antiinflammatory and analgesic drug with an IC50 of 4.9 µM, related in structure to non-steroidal antinflammtory drugs (NSAIDs) such as indometacin. It was developed in the 1980s as a new antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX).
High Quality Content by WIKIPEDIA articles! Pravastatin (marketed as Pravachol or Selektine) is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease. Initially known as CS-514, it was originally identified in a bacterium called Nocardia autotrophica by researchers of the Sankyo Pharma Inc.. It is presently being marketed outside Japan by the pharmaceutical company Bristol-Myers Squibb.
High Quality Content by WIKIPEDIA articles! Prazepam is a benzodiazepine derivative drug developed by Warner-Lambert in the 1960s. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Prazepam is a prodrug for desmethyldiazepam which is an active metabolite of prazepam. Desmethyldiazepam is responsible for the therapeutic effects of prazepam.
High Quality Content by WIKIPEDIA articles! Praziquantel (Biltricide) is an anthelmintic effective against flatworms. Praziquantel is not licensed for use in humans in the UK; it is, however, available as a veterinary anthelmintic, and is available for use in humans on a named-patient basis.
High Quality Content by WIKIPEDIA articles! Prazitone (AGN-511) is a barbiturate derivative invented in the 1970s. Unlike most barbiturates, it has little or no sedative effects, instead acting as a non-sedating anxiolytic and antidepressant. The dosage range in humans is around 200-600 mg, although higher doses have been used in trials for the treatment of depression associated with Parkinson`s disease.
High Quality Content by WIKIPEDIA articles! Prazosin, trade names Minipress, Vasoflex, Pressin and Hypovase, is a sympatholytic drug used to treat high blood pressure and Anxiety, PTSD and Panic Disorder. It belongs to the class of alpha-adrenergic blockers. Specifically, prazosin is selective for the alpha-1 receptors on vascular smooth muscle. These receptors are responsible for the vasoconstrictive action of norepinephrine, which would normally raise blood pressure and cause increase in anxiety and panic. By blocking these receptors, prazosin reduces blood pressure and reduces anxiety and panic.
High Quality Content by WIKIPEDIA articles! Premarin is the commercial name for a compound cream of vaginally administered estrogens, consisting primarily of conjugated estrogens. Isolated from mares` urine (PREgnant MARes` urINe), it is manufactured by Wyeth Pharmaceuticals (part of Pfizer since January 2009) and has been marketed since 1942. It is available in oral (0.3/ 0.45/ 0.625/ 0.9/ 1.25 mg), IV, and topical form.
High Quality Content by WIKIPEDIA articles! Pridopidine (Huntexil, formerly ACR16) is an experimental drug candidate belonging to a class of agents known as dopidines, which act as dopaminergic stabilizers in the central nervous system. These compounds may counteract the effects of excessive or insufficient dopaminergic transmission, and are therefore under investigation for application in neurological and psychiatric disorders characterized by altered dopaminergic transmission, such as Huntington`s disease (HD).
High Quality Content by WIKIPEDIA articles! Primidone is an anticonvulsant of the pyrimidinedione class, the active metabolites of which, phenobarbital (major) and phenylethylmalonamide (PEMA) (minor), are also anticonvulsants. It is used mainly to treat complex partial, simple partial, generalized tonic-clonic seizures, myoclonic, and akinetic seizures and since the 1980s it has been a valuable alternative to propranolol in the treatment of essential tremor. Unlike other anticonvulsants such as carbamazepine and valproic acid, primidone is rarely used in the treatment of bipolar disorder or any other psychiatric problem. It is also not widely used in treatment of neuropathic pain, trigeminal neuralgia, migraine and essential tremor....
High Quality Content by WIKIPEDIA articles! Prismane is a polycyclic hydrocarbon with the formula C6H6. It is an isomer of benzene, more specific: a valence isomer. Prismane is far less stable than benzene. The carbon (and hydrogen) atoms of the prismane molecule are arranged in the shape of a six-atom triangular prism. Albert Ladenburg proposed this structure for the compound now known as benzene. The compound was not synthesized until 1973.
High Quality Content by WIKIPEDIA articles! Procarbazine (Matulane (US), Natulan (Canada), Indicarb (India) is an antineoplastic chemotherapy drug for the treatment of Hodgkin`s lymphoma and certain brain cancers (such as Glioblastoma multiforme). It is a member of a group of medicines called alkylating agents. It gained FDA Approved in July 1969. The drug is metabolized and activated in the liver. It also inhibits MAO thus increasing the effects of sympathomimetics, TCAs, and tyramine.
High Quality Content by WIKIPEDIA articles! Progabide (INN) (trade name Gabrene, Sanofi-Aventis) is an analog and prodrug of gamma-aminobutyric acid used in the treatment of epilepsy. It has agonistic activity at both the GABAA and GABAB receptors.
High Quality Content by WIKIPEDIA articles! Cornish promontory forts, commonly known in Cornwall as cliff castles, are coastal equivalents of the hill forts and Cornish "rounds" found on Cornish hilltops and slopes. Similar coastal forts are found on the north–west European seaboard, in Normandy, Brittany and around the coastlines of the British Isles, especially in Wales, Scotland and Ireland. Many are known in southwest England, particularly in Cornwall and its neighbouring county, Devon. Two have been identified immediately west of Cornwall, in the Isles of Scilly.
High Quality Content by WIKIPEDIA articles! Propane is a three-carbon alkane with the molecular formula C3H8, normally a gas, but compressible to a transportable liquid. A by-product of natural gas processing and petroleum refining, it is commonly used as a fuel for engines, oxy-gas torches, barbecues, portable stoves, and residential central heating.
High Quality Content by WIKIPEDIA articles! An orbital propellant depot is a cache of propellant that is placed on an orbit about the Earth or another body to allow spacecraft to be fueled in space. Launching a spacecraft separately from some of its propellant enables missions with more massive payloads. It also facilitates life extension for satellites that have nearly reached end-of-life by consuming nearly all of their orbital maneuvering fuel. The spacecraft would conduct a space rendezvous with the depot, or vice versa, and then transfer propellant to be used for subsequent orbital maneuvers. An in-space fuel depot (alternative name) is not necessarily located near or at a space station.