High Quality Content by WIKIPEDIA articles! Sabcomeline (Memric; SB-202,026) is a selective M1 receptor partial agonist that was under development for the treatment of Alzheimer`s disease. It made it to phase III clinical trials before being discontinued due to poor results.
High Quality Content by WIKIPEDIA articles! Saclofen is a competitive antagonist for the GABAB receptor. This drug is an analogue of the GABAB agonist Baclofen. The GABAB receptor is heptahelical receptor, expressed as an obligate heterodimer, which couples to the Gi/o class of heterotrimeric G-proteins. The action of saclofen on the central nervous system is understandably modest, because G-proteins rely on an enzyme cascade to alter cell behavior while ionotropic receptors immediately change the ionic permeability of the neuronal plasma membrane, thus changing its firing patterns. These particular receptors, presynaptically inhibit N- and P/Q- VGCCs via a direct interaction of the dissociated beta gamma subunit of the g-protein with...
High Quality Content by WIKIPEDIA articles! Safinamide (EMD 1195686) is a candidate drug against Parkinson`s disease with multiple methods of action. In 2007, a Phase III clinical trial was started. It is scheduled to run until 2011. The drug will be marketed by Merck-Serono.
High Quality Content by WIKIPEDIA articles! Safranal is an organic compound isolated from saffron, the spice consisting of the stigmas of crocus flowers (Crocus sativus). It is the constituent primarily responsible for the aroma of saffron.
High Quality Content by WIKIPEDIA articles! Safrazine (Safra) is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used introduced as an antidepressant in the 1960s, and is still used in Japan today.
High Quality Content by WIKIPEDIA articles! Safrole, also known as shikimol, is a phenylpropene. It is a colorless or slightly yellow oily liquid. It is typically extracted from the root-bark or the fruit of sassafras plants in the form of sassafras oil (although commercially available sassafras oil is usually devoid of safrole via a rule passed by the FDA in 1960, see here), or synthesized from other related methylenedioxy compounds. It is the principal component of brown camphor oil, and is found in small amounts in a wide variety of plants, where it functions as a natural pesticide. Ocotea cymbarum oil made from Ocotea pretiosa, a plant growing in Brazil, and sassafras oil made from Sassafras albidum, a tree growing in eastern North...
High Quality Content by WIKIPEDIA articles! Santonin is a drug which was widely used in the past as an anthelminthic, a drug that expels parasitic worms (helminths) from the body, by either killing or stunning them. Santonin was formerly listed in U.S. and British pharmacopoeia but has fallen out of use with the development of safer ascaricides and is no longer registered as a drug in most countries.
High Quality Content by WIKIPEDIA articles! Saquinavir is an antiretroviral drug used in HIV therapy. It falls in the protease inhibitor class. Two formulations have been marketed:
High Quality Content by WIKIPEDIA articles! SB-271,046 is a drug which is used in scientific research. It was one of the first selective 5-HT6 receptor antagonists to be discovered, and was found through high-throughput screening of the SmithKline Beecham Compound Bank using cloned 5-HT6 receptors as a target, with an initial lead compound being developed into SB-271,046 through a structure-activity relationship (SAR) study. SB-271,046 was found to be potent and selective in vitro and had good oral bioavailability in vivo, but had poor penetration across the blood-brain barrier, so further SAR work was then conducted, which led to improved 5-HT6 antagonists such as SB-357,134 and SB-399,885.
High Quality Content by WIKIPEDIA articles! The Streptavidin-Binding Peptide (SBP)-Tag is a 38-amino acid sequence that may be engineered into recombinant proteins. Recombinant proteins containing the SBP-Tag bind to streptavidin and this property may be utilized in specific purification, detection or immobilization strategies.
High Quality Content by WIKIPEDIA articles! Scheele`s Green, also called Schloss Green, is chemically a cupric hydrogen arsenite (also called copper arsenite or acidic copper arsenite), CuHAsO3. It is a compound similar to Paris Green. It is a green pigment, of yellowish hue and was used in the past in some paints but has since fallen out of use due to its toxicity.
High Quality Content by WIKIPEDIA articles! Schwartz`s reagent is the common name for the chemical compound with the formula (C5H5)2ZrHCl, sometimes described zirconocene hydrochloride or zirconocene chloride hydride and is named after Jeffrey Schwartz, who is currently a professor in Chemistry at Princeton University. This metallocene is used in organic synthesis for various transformations of alkenes and alkynes.
High Quality Content by WIKIPEDIA articles! Sclareol is a fragrant chemical compound found in clary sage (Salvia sclarea), from which it derives its name. It is classified as a bicyclic diterpene alcohol. It is an amber colored solid with a sweet, balsamic scent.
High Quality Content by WIKIPEDIA articles! Nanotube chemistry is a field in chemistry devoted to the study of carbon nanotubes specifically functionalization of single-walled nanotubes.
High Quality Content by WIKIPEDIA articles! Selenomethionine is an amino acid containing selenium. The L-enantiomer of selenomethionine, known as Se-met and Sem, is a common natural food source of selenium. In vivo, selenomethionine is randomly incorporated instead of methionine and is readily oxidized. Its antioxidant activity arises from its ability to deplete reactive species. Selenium and sulfur are chalcogen elements that share many chemical properties and the substitution of methionine to selenomethionine may have no effect on protein structure and function. However, the incorporation of selenomethionine into tissue proteins and keratin in horses causes alkali disease. Alkali disease is characterized by emaciation, loss of hair,...
High Quality Content by WIKIPEDIA articles! Although it is toxic in large doses, selenium is an essential micronutrient for animals. In plants, it sometimes occurs in amounts toxic as forage, e.g. locoweed.. Selenium is a component of the amino acids selenocysteine and selenomethionine. In humans, selenium is a trace element nutrient that functions as cofactor for glutathione peroxidases and certain forms of thioredoxin reductase. Selenium-containing proteins are produced from inorganic selenium via the intermediacy of selenophosphate (PSeO33-).
High Quality Content by WIKIPEDIA articles! Selenite, satin spar, desert rose, and gypsum flower are four varieties of the mineral gypsum; all four varieties show obvious crystalline structure. The four "crystalline" varieties of gypsum are sometimes grouped together and called selenite.